Genetic variants associated with Alzheimer’s Disease
Suppose you are the Principal Investigator (PI) on a large study aiming to identify genetic variants associated with Alzheimer’s Disease. You have collected samples from 2,000 cases, 2,000 controls, and genotyped them using the Illumina Infinium Omni5-4 Kit commercial genotyping array. You perform single SNP association disease analysis, and you do not identify any associations that are statistically significant, after adjusting for multiple testing. You have spent 5 years, and several million $, on collecting and analyzing these samples. What does this mean, and what would you do next? Comment on:
- What could be potential causes (give at least 5) for not finding any significant associations, and mention potential solutions?
- How could pathway analysis help your project?
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